Spinophilin and Psychostimulants
Current people - Basant Hens
Previous external funding - NIDA R21/R33. Current external funding - NIDA R01 pending review

One project focuses on spinophilin-dependent regulation of psychostimulant locomotor sensitization and self-administration. Specifically, understanding how loss of spinophilin in different striatal cell types impacts dopamine D2R function as well as behavioral responses to psychostimulants and D2R agonists.

Psychostimulant Sensitization
Current people - Nikhil Shah
Current external funding - NINDS R01 pending review

A second project in the laboratory focuses on the interesting observation that spinophilin and neurabin have differential roles in regulating motor learning. In this project, we are using our recently generated and validated spinophilin conditional knockout mouse line as well as our recently generated neurabin conditional knockout line to detail striatal and cerebellar-depednent motor learning

Spinophilin in pancreatic islets
Current people - Kaitlyn Stickel
Current external funding - NIDDK R01 pending submission

We sometimes think outside the brain. Kaitlyn is currently finishing up a manuscript that we hope to submit by the end of 2022, detailing the role of spinophilin in pancreatic tissue and on weight gain and glucose tolerance in different obesity models.

Spinophilin and neurabin PP1 targeting
Current people - Emily Claeboe
Current external funding - NINDS R21 pending review

As the major synaptic PP1 targeting proteins, Emily is currently working on understanding how spinophilin and neurabin impact synaptic PP1 targeting and on designing ways to inhibit synaptic-targeted PP1 activity